The Les Bleus star says it would be a different feel with no fans in the stadium due to COVID-19.
Barcelona hold a two-point lead over arch-rivals Real Madrid.
France international Antoine Griezmann believes it would be "very strange" to play behind closed doors amid the coronavirus chaos.
The 2019-20 LaLiga campaign which came to a standstill in March - due to the COVID-19 outbreak - is set to resume on June 11, and Barcelona’s first game will be away to Mallorca on June 13.
However, Barca ace Griezmann, who has clearly missed the football pitch, says he had a good time with his family during the lockdown.
"The first game will be in Mallorca, but it will be very strange to play without an audience," Griezmann, who has scored 14 goals in 37 games for Los Cules this season, said during a conversation on Twitch on Thursday.
"It will be the first time I have experienced something like this."
The former Atletico Madrid attacking midfielder added: "I had never been so long stopped.
"Yes, it is true that during these days I was able to enjoy my children (during the coronavirus shutdown)."
The Blaugrana lead the LaLiga Santander table by two points, and have 11 rounds left to defend the title.