This will be Setien's third game in charge as Barca boss following wins over Granada and minnows UD Ibiza.
Barcelona head coach Quique Setien says he is ready for their clash against Valencia, acknowledging that 'it is going to be a very high-level game'.
This will be Setien's third game in charge as Barca boss following a LaLiga win over Granada last weekend and their Copa Del Rey victory over minnows UD Ibiza two days ago.
The Blaugrana have struggled to secure wins away from home this season as they've dropped points at Athletic Bilbao, Osasuna, Granada, Levante, Real Sociedad and Espanyol.
Speaking ahead of the match at the Estadio de Mestalla stadium on Saturday, the 61-year-old said: “I am not expecting any less from this game or the remaining matches.
“The opposition may be one of the top sides that you can face, but you have to pass tests every day. It is going to be a very high-level game, I am sure.”
Valencia, who are seventh in the LaLiga table, lost 4-1 away at Mallorca and they'll be keen to bounce back to winning ways when they host the defending champions this weekend.
Setien added: “It is true that when a side like Valencia loses their previous game then their desire to change that is an incentive.
“I am always expecting the best side, and Valencia are definitely a great side with very good players. They will make things very difficult for us.
“Maybe we have the possibility of doing them more damage, but they are also a team that can attack you and I am sure they will do that.”