The next tie for City is the visit of arch rivals Man United.
The Premier League champions cruised to victory after Fulham captain Tim Ream was sent of for a foul on Gabriel Jesus.
Pep Guardiola is looking forward to their EFL Cup semi-final second-leg clash against Manchester United after his Manchester City side secured a 4-0 win over Fulham in the FA Cup fourth round.
The Premier League champions cruised to victory after Fulham captain Tim Ream was sent of for a foul on Gabriel Jesus inside the box in the opening eight minutes.
Ilkay Gundogan converted the penalty as Bernardo Silva increased the lead nine minutes later, before Jesus' second-half double put the icing on the cake for the Citizens on Sunday.
Speaking after the match with Championship side Fulham at the Etihad, Guardiola said as Reuters quoted: "For a few moments, I thought it would be a tough game.
"They're a team with a lot of courage but it was a bit different after the red card. They still tried to play but the game was over at 3-0.
"The determination was always there and we will fight to win each competition.
"Always we score goals and have the ability to score. The problem this season has been conceding some goals, but it's always good to score goals."
Regarding Wednesday's derby [the second leg of their EFL Cup semi-final] in which City have a 3-1 aggregate lead, the Spaniard added: "Next is United and a chance to get to the final and that is our next target."