Liverpool have to be brave against City on Thursday.
The German's Reds travel to the Etihad tomorrow and can make it 10 points clear at the summit if they seal a win over Pep Guardiola's Citizens.
Tottenham moved above City to second spot following their 3-0 win over Cardiff, however Klopp says City 'are a really strong football team with an outstanding manager'.
"It is a normal game against Manchester City but a very difficult one, one of the most difficult you can play in modern football," he said.
"They are a really strong football team with an outstanding manager. Before you play them, you never know.
"We have to be prepared as good as possible, be brave, full of desire and angry again like in all the other games.
"The opponent is, for me, still the best in the world."