The Reds' British record signing Angel di Maria won't be available for their home clash against Stoke City due to a hamstring problem as he was taken off in their 3-0 win over Hull City on Saturday.
Captain Rooney will be available for selection as he's expected to overcome the bang he got on his knee, while Radamel Falcao is in contention to start for the Red Devils.
Stoke central midfielder Sidwell will be out for six weeks due to a knee ligament injury [according to reports] he got in thier 1-0 defeat to Liverpool at Anfield.
Mark Hughes' side have a few players out due to injury: Victor Moses (thigh), Robert Huth (calf), Peter Odemwingie (knee) and Dionatan Teixeira (broken foot) and former Sunderland right back Phil Bardsley could be available for selection after missing the match on Saturday.
Van Gaal said it'll be a different kind of test for his side but hopes to secure three points which would make it their fourth win on the bounce under the Dutchman.
Kick-off: Tuesday 7:45pm. Venue: Old Trafford.
Referee: Jonathan Moss.
Predicted start XI for Manchester United: De Gea Valencia, Smalling, Rojo, Young, Carrick, Herrera, Fellaini, Mata, Rooney and Van Persie.
Predicted start XI for Stoke City: Begovic, Bardsley, Cameron, Shawcross, Pieters, Walters, Nzonzi, Adam, Bojan, Crouch and Diouf.
Written by @Chukkymufc