Louis van Gaal's side face Tottenham who are just three points behind United in fourth place, in the race for securing a top four spot this season.
After a 2-1 defeat to Arsenal on Monday night saw the Red Devils lose out on a place in the semi-final of the FA Cup, now is the time they need to step up and bounce back with a win over Pochettino's men - who are also involved in the rat race for a Champions League place.
As for Spurs, Harry Kane continues to show he can be relied on when needed. He scored two goals against QPR last Saturday increasing his tally for the campaign to 24 and after just picking up the Player-of-the-month award on Friday, the 21-year-old and his team-mates will definitely be looking to cause an upset at Old Trafford on Sunday.
Kick-off: Sunday 4pm.
Venue: Old Trafford.
Referee: M Clattenburg.
Man Utd Predicted starting XI: Rooney, Falcao, Fellaini, Blind, Ashley Young, Valencia, Carrick, Mc Nair, Rojo, Smalling, Rafael.
Manchester United Form: WDWLWW.
Spurs predicted starting XI: Kane, Chadli, Eriksen, Townsend, Mason, Bentaleb, Rose, Walker, Vertoghen, Dier, Lloris.
Tottenham Hotspur Form: WWLDWW